- Patriot: the best lethal weapon of the game with infinite ammo
- Single Action Army: Ocelot’s weapon
- AT-Camo: multiplies your camo index of the equipped camo. You can obtain it only by finding and shooting all 64 Ga-ko.
- EZ Gun (Special Item): non-lethal weapon that grants infinite stamina. You can obtain it only if you collect and eat each of the 48 food. On Very Easy difficult, you have EZ Gun from the start.
- Infinite Face Paint (Special Item): it grants infinite ammo for every weapon. You can obtain it only if you capture and keep alive the Tsuchinoko, or if you obtain the Foxhound rank.
- Stealth Camo (Special Item): makes you invisible from enemies. You can obtain it only by finding and shooting all 64 Kerotans, or by beating the game with zero alerts.
- Secret Theater: with hidden film reel obtainable during the playthrough from specific enemies.
- Special Camo unlockable by beating the game:
Mummy: gives auto-healing from injuries that require a bandage You can get this camo beating the game on any difficulty, or selecting “I’m playing the MGS series for the first time” when you start the game.
DPM: gives you double health recovery and stamina rate. You can acquire this camo beating the game on any difficulty, or selecting “I like MGS1” when you start the game.
Auscam: reduces damage taken by 2/3. You can obtain this camo beating the game on any difficulty, or selecting “I like MGS1” when you start the game.
Desert Tiger: grants infinite suppressor use. You can obtain this camo beating the game on any difficulty, or selecting “I like MGS2” when you start the game.
Flecktran: grants infinite battery for thermal goggles. You can acquire this camo beating the game on any difficulty, or selecting “I like MGS3” when you start the game.
Banana: makes all food taste great. You can get this camo beating the game on any difficulty, or selecting “I like MGS Peace Walker” when you start the game.
Grenade: grants infinite grenades. You can acquire this camo beating the game on any difficulty, or selecting “I like everything in MGS series” when you start the game
Special Face Paint unlockable by beating the game:
Green: wearing it gives infinite grip gauge. You can acquire this face paint beating the game on any difficulty, or selecting “I like everything in MGS series” when you start the game.
Brown: equipping it grants infinite oxygen. You can get this face paint beating the game on any difficulty, or selecting “I like everything in MGS series” when you start the game.
Other Camo unlockable by beating the game:
These camos don’t give you special abilities. They can be useful to increase camo index in specific areas.
- Anubis
- Watersnake
- Night Desert
- Rock
- Swamp
- Dododo
- Festival
- Flower
- Barracuda
- Rainbow
- Chameleon
- KLMK
- Urban Tiger
- Soviet Woodland
- Former West Germany
- Valentine
- Former East Germany
- Tuxedo
- Santa Claus
- Flag Decorative Face Paints